Endocrine Abstracts

Introduction: Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene which may influence the function of white adipose tissue (WAT).Objective: To study the role of AIF-1 in human WAT.Design and main outcome measures: mRNA expression and WAT secretion of AIF-1 was determined in subcutaneous and visceral WAT from non-obese subjects. Differentiated human adipocytes were treated with recombinant AIF-1 in vitro.<p...

Context: Alterations in white adipose tissue (WAT) function, including changes in extracellular matrix (ECM) composition, play an important role in conditions of both weight gain and loss.Objective: We set out to identify novel genes regulated by obesity and cancer cachexia in human scWAT with potential roles for adipocyte function and/or tissue remodelling.Design Candidate genes were selected by overlapping previously published gl...